Ubiquilin 3 polyclonal antibody

Ubiquitin (Ub) is among the most phylogenetically conserved proteins known. The primary function of this small, 76 amino acid protein is to clear abnormal, foreign and improperly folded proteins by targeting them for degradation by the 26S proteosome. Many ubiquitin-like proteins function as post-translational protein modifiers, such as members of the SUMO protein family, however some ubiquitin-like proteins regulate protein-protein interactions and cell cycle events, thereby functioning outside of the traditional ubiquitination pathway. UBQLN3 (Ubiquilin-3) is a 654 amino acid protein containing one N-terminal ubiquitin-like (UBQ) domain and one C-terminal UBA domain. With expression limited to testis, it has been suggested that UBQLN3 may associate with testis-specific cyclin A1 and/or cyclin A to regulate the cell cycle during spermatogenesis. Similarly, a family member related to UBQLN3, namely PLIC-1, also known as Ubiquilin-1, may also play a critical role in cell cycle regulation.