DCLRE1B polyclonal antibody

DNA interstrand cross-links (ICLs) pose lethal threats to DNA as they inhibit segregation, replication and transcription. The mechanism of ICL repair is complex but is at least partly conserved between Saccharomyces cerevisiae and mammals. SNM1B (SNM1 homolog B), also known as DCLRE1B [DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae]) or APOLLO, is a 532 amino acid nuclear protein that localizes to discrete foci and is likely required for DNA interstrand cross-link repair. SNM1B assists in the maintenance of telomeres during S-phase and interacts with TRF2 (telomeric repeat binding factor 2), a protein involved in telomeric organization and protection, in the early DNA-damage response. A member of the DNA repair metallo-β-lactamase (DRMBL) family, SNM1B becomes phosphorylated following translation, either by ATM or ATR, and is encoded by a gene located on human chromosome 1.