TRIM68 polyclonal antibody

The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM68 (tripartite motif-containing protein 68), also known as RNF137 (RING finger protein 137) or SS56, is a 485 amino acid protein that localizes to the perinuclear region of the cytoplasm. Expressed in a variety of tissues with higher expression in prostate, spleen and fetal liver, TRIM68 associates with androgen receptor (AR) and, via this interaction, enhances the transcriptional activity of AR. TRIM68 is found in various cancers, including prostate cancer cells, and is thought to be a therapeutic target for the detection and treatment of prostate cancer. Additionally, TRIM68 is a target of the autoimmune response exhibited in systemic lupus erythematosus (SLE), primary Sjoegren syndrome and HIV-1 infection.