SLC9A8 polyclonal antibody

Na+/H+ exchangers 1-8, also designated Na+/H+ antiporters or NHE-1-8, are integral membrane proteins expressed in most mammalian tissues where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, NHE isoforms 2-8 have distinct tissue and cell type dependent expression and inhibitory characteristics. NHE-8 is a 575 amino acid protein that localizes apically in intestinal epithelial cells. Expression of NHE-8 is higher in young mammals than adults. NHE-8 gene and protein expression are highly regulated during ontogeny; this protein may play an important role in intestinal Na+ absorption during early mammalian life.