IARS2 polyclonal antibody

The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Proteins belonging to this family function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. IARS2 (Isoleucyl-tRNA synthetase), also known as IleRS (Isoleucine-tRNA ligase), is a 1012 amino acid protein that is localized within the mitochondrial matrix. Specifically belonging to the class I mitochondrial aminoacyl-tRNA synthetase family, IARS2 contains a characteristic Rossman fold, which is found in proteins that typically bind nucleotides. The gene encoding IARS2 maps to human chromosome one, which is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.