EID1 polyclonal antibody

E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme,
binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue
specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional
co-activator protein. EID-1 inhibits cellular differentiation by blocking
the histone acetyltransferase activity of p300. EID-1 also acetylates both
histones and non-histone proteins such as NCOA3 co-activator. By acetylating
histones, EID-1 gives a specific tag for transcriptional activation. In addition
to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein,
mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated
CREB and activates transcription of cAMP responsive genes as a
co-activator.