DUS2L polyclonal antibody

DUS2L (tRNA-dihydrouridine synthase 2-like), also known as URLC8 (upregulated in lung cancer protein 8) or SMM1, is a 493 amino acid member of the DUS protein family. Localized to cytoplasm and endoplasmic reticulum, DUS2L uses FAD as a cofactor to catalyze the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. DUS2L contains one DRBM (double-stranded RNA-binding) domain and has been found to interact with ProRS. DUS2L is upregulated in most lung cancer cells and has weak expression in normal heart, skeletal muscle and placenta. The gene that encodes DUS2L maps to human chromosome 16q22.1 and murine chromosome 8 D3.