USP37 polyclonal antibody

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP37 (ubiquitin specific peptidase 37) is a 979 amino acid protein that contains three UIM (ubiquitin-interacting motif) repeats and belongs to thepeptidase C19 family. Expressed in prostate and brain tissue, USP37 functions to catalyze the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP37 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome.