TSHZ2 polyclonal antibody

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. TSHZ2 (Teashirt homolog 2), also known as ZNF218 (Zinc finger protein 218) and OVC10-2 (Ovarian cancer-related protein 10-2), is a 1034 amino acid nuclear protein that contains one homeobox DNA-binding domain, as well as five C2H2-type zinc fingers. In drosophilia, teashirt genes function as region-specific homeotic genes that specify trunk identity during embryogenesis and these genes seem to conserve the same function in mice. The gene encoding TSHZ2 maps to human chromosome 20, which comprises approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.