SDCCAG8 polyclonal antibody

SDCCAG8 (serologically defined colon cancer antigen 8), also known as CCCAP (centrosomal colon cancer autoantigen protein), HSPC085 or NY-CO-8, is a 713 amino acid cytoplasmic protein that is expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa and renal cancer tumors. Existing as a homodimer, SDCCAG8 localizes to centrioles and interacts with oral-facial-digital syndrome 1 (ODF1), which is associated with nephronophthisis-related ciliopathies (NPHP-RC), a recessive disorder that is characterized by dysplasia or degeneration of the kidney, retina and cerebellum. SDCCAG8 exists as four alternatively spliced isoforms and is encoded by a gene located on humanc chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.