INHBB polyclonal antibody

The TGFβ superfamilyis composed of numerous growth and differentiation
factors, including transforming growth factor β (TGFβ) 1, 2 and 3; growth/
differentiation factor (GDF) 1 through 8;Mullerian inhibiting substance (MIS);bone morphogenic protein (BMP) 2 through 8; glialcell line-derived neurotrophic factor (GDNF); Inhibins(α, β-A, β-B and β-C),Lefty and Nodal. Members of the TGFβ superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activinsinhibit and activate, respectively, the secretion of follitropin bythe pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothala mic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, Insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. activins oppose the funtions of Inhibins. Inhibins are predominantly expressed in liver, uterus and ovarytissue. Inhibin A, a dimer ofαand β-A, and Inhibin B, a dimer of α and β-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin β-C forms a homodimer and its expression is predominant in adult liver.