IL1R2 polyclonal antibody

Decoy receptors are structurally incapable of activating signaling pathways, but act as anti-inflammatory agents by sequestering agonists for actual signaling complexes. The type II IL-1 receptor (IL-1RII) acts as a decoy receptor for the chemokine interleukin-1 (IL-1). Additionally, the soluble form of IL-1R accessory protein (IL-1R AcP) increases the affinity of binding of IL-1α and IL-1β to IL-1RII 100-fold, but does not increase the affinity for another antiinflammatory agent, IL-1R antagonist (IL-1Ra). The end result is a complex regulatory mechanism for IL-1 activated inflammation, whereby dexamethasone and other molecules inducing IL-1RII, function in an immunosupressive and anti-inflammatory manner.