MESP2 polyclonal antibody

MESP2 (mesoderm posterior 2 homolog), also known as SCDO2 or bHLHc6 (class C basic helix-loop-helix protein 6), is a 397 amino acid protein that contains one basic helix-loop-helix (bHLH) domain, a motif that mediates protein dimerization and can bind to the E-box sequence of DNA. Localized to the nucleus, MESP2 functions as a transcription factor that, via its bHLH domain, participates in the epithelialization and the development of the cardiac and somitic mesoderm. MESP2 is involved in somitogenesis and Notch pathways and is encoded by a gene that maps to human chromosome 15q26.1. Defects in the MESP2 gene are the cause of an autosomal recessive disorder known as spondylocostal dysostosis type 2 (SCDO2).