Skip to product information
1 of 1

Bioworld

SKU:BS1157

GSK3β (S13) polyclonal antibody

GSK3β (S13) polyclonal antibody

Regular price $325.00 USD
Regular price Sale price $325.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
Host
Reactivity

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.

View full details