PFKL (E724) polyclonal antibody

Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis. There are three isozymes: muscle-type, liver-type, and platelet-type. The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver. Research studies have shown that because of its location on chromosome 21, this enzyme is overexpressed in Down Syndrome/trisomy 21. PFKL also may have a role in the physiological response to a low fat diet.