TRH-R1 (W234) polyclonal antibody

Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones.