ZDHHC9 (K364) polyclonal antibody

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC9 (zinc finger, DHHC-type containing 9), also known as DHHC9, CGI-89, ZNF379 or CXorf11, is a 364 amino acid protein that localizes to the membrane of the endoplasmic reticulum and contains one DHHC-type zinc finger. Expressed at high levels in brain, lung, kidney, liver and skeletal muscle, ZDHHC9 exists in a complex with GOLGA7 and, via its DHHC domain, functions as a palmitoyltransferase that is specific for H-Ras and N-Ras. Mutations in the gene encoding ZDHHC9 are associated with X-linked mental retardation and colorectal cancer, the latter of which suggests a role in tumorigenesis.