MaxiKβ (K119) polyclonal antibody

MaxiK channels are large conductance voltage and Ca 2+-activated potassium channels which are formed by tetramers of MaxiKα subunits, which create pores that are used for smooth muscle tone and neuronal excitability. These MaxiKα subunits have the ability to coassemble with MaxiKβ subunits that are structurally related and are able to regulate the function of MaxiKα subunits. KCNMB4 (potassium large conductance calcium-activated channel, subfamily M, β member 4), also known as Slo-β-4 or Maxi K channel subunit β-4, is a 210 amino acid multi-pass membrane protein belonging to the KCNMB family. Predominantly expressed in brain, KCNMB4 is a regulatory subunit of the calcium activated potassium MaxiKα channel. KCNMB4 contributes to MaxiKα channel diversity by modulating calcium sensitivity and gating kinetics of MaxiKα.