OAZ1 polyclonal antibody

Antizyme 1 (AZ1) negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. Polyamines are involved in cell cycle and cell growth, and thus the interaction between AZ1 and ODC functions in this process as well, in a regulatory manner. Furthermore, treatment of cells with leptomycin B, an inhibitor of chromosomal maintenance proteins, causes the relocation of AZ1 to the nucleus, suggesting a novel function of AZ1 not associated with the proteasome.