TRAPPC5 polyclonal antibody

TRAPPC5 (trafficking protein particle complex 5), also known as TRS31, is a 181 amino acid protein belonging to the TRAPP (transport protein particle) small subunits family and the BET3 subfamily. Encoded by a gene that maps to human chromosome 19p13.2, TRAPPC5 is part of the multisubunit TRAPP tethering complex,which acts as a GTP exchange factor. Evolutionarily conserved, TRAPPC5 plays a role in protein binding,vesicle-mediated transport and nucleotide exchange stimulation. TRAPPC5 also performs guanine nucleotide exchanger factor (GEF) functions both in vitro and in vivo.Localizing to the Golgi apparatus, TRAPPC5 is essential for endoplasmic reticulum(ER)-to-Golgi and intra-Golgi vesicle trafficking in yeast, aswell as additional transport events in mammals,such as post--Golgi trafficking.