SOX17 polyclonal antibody

Transcription factor Sox17 is a Sox family protein with an established role in endoderm specification during development. In addition, Sox17 plays essential roles in the maintenance of the hematopoietic stem cell pool and for vascular morphogenesis during development. Sox17 negatively regulates oligodendrocyte precursor differentiation by antagonizing β-catenin signaling. Mutation in the corresponding Sox17 gene in humans is associated with a form of vesicoureteral reflux, a disorder characterized by congenital kidney and urinary tract defects.