CIDEB polyclonal antibody

The DNA fragmentation factor (DFF) is involved in the caspase-3 apoptotic
pathway. DFF is composed of two subunits, a 45 kDa subunit called DFF-45
(also designated ICAD, for inhibitor of CAD), and CPAN (caspase-activated
nuclease), also designated CAD (caspase-activated deoxyribonuclease).
CPAN is a DNase that is responsible for DNA degradation during apoptosis.
CPAN is inhibited by DFF-45. Caspase-3 acts to dissociate CPAN from DFF-45,
allowing CPAN to enter the nucleus and degrade DNA. CIDE-A and CIDE-B
have been identified as proteins that share homology with the N-terminal
region of DFF-45. Like CPAN, CIDE-A and CIDE-B promote cell death and
DNA fragmentation and are inhibited by DFF-45.