PRPF19 polyclonal antibody

The spliceosome, the gigantic molecular machine that performs pre-mRNA
splicing in eukaryotes, contains over 200 different proteins and 5 RNA
molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove
internal non-coding regions of pre-mRNA (introns) and to join the remaining
segments (exons) into mRNA before translation. The PRP19-associated complex
is required for stable association of U5 and U6 with the spliceosome
after U4 is released. Changes within the spliceosome upon binding of the
PRP19-associated complex include remodeling of the U6/5' splice site interaction
and destabilization of Lsm proteins to allow further interaction of U6
with the intron sequence.