UBE2A/UBE2B polyclonal antibody

The ubiquitin-conjugating (UBC) enzymes HR6A and HR6B are the mammalian orthologues of the Saccharomyces cerevisiae Rad6 gene products. In S. cerevisiae, Rad6 facilitates cell cycle progression and ubiquitinates histone H2B. In vivo phosphorylation of HR6A Ser120 by cyclin-dependent kinases is thought to be important for the coordination and timing of ubiquitination events involved in cell cycle progression. In response to DNA damage, HR6A is known to interact physically with p53 and p14ARF, but knockout mice lacking HR6A or HR6B exhibit normal DNA damage responses. HR6B knockout males exhibit defective spermatogenesis, while HR6A knockout females fail to produce viable offspring.