MRPL41 polyclonal antibody

Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-L41 (mitochondrial ribosomal protein L41), also known as cell proliferation-inducing gene 3 protein and BMRP (Bcl-2-interacting mitochondrial ribosomal protein L41), is a 137 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 39S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. Expressed in liver, testis, kidney and thymus, MRP-L41 is in-volved in the cell cycle and apoptosis. Possibly by stabilizing p21 and p27, MRP-L41 has the ability to arrest the cell cycle in the G1 phase. MRP-L41 also enhances p53 stability, therefore contributing to p53-induced apoptosis in response to growth-inhibitory conditions