USP30 polyclonal antibody

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP30 (ubiquitin specific peptidase 30) is a 517 amino acid protein that localizes to the mitochondrion and belongs to the ubiquitin-specific protease family.
Expressed in pancreas, kidney, liver and skeletal muscle, USP30 functions to catalyze the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP30 maps to human chromosome 12q24.11, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.