TMPRSS2 polyclonal antibody

Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate.Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells.In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).