TIM3 polyclonal antibody

T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecule that is induced following T cell activation . TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer , and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype . Tumor-infiltrating dendritic cells (DCs) also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells . Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer . In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease . Finally, binding of Galectin-9 to TIM-3 expressed by Th1 cells induces T cell death .