CD10 monoclonal antibody

CD10, also known as neprilysin, common acute lymphoblastic leukemia antigen (CALLA) or neutral endopeptidase (NEP), is a zinc-dependent transmembrane metallo-endopeptidase. CD10 cleaves peptides at the N-terminal side of hydrophobic amino acid residues and deactivates a variety of signaling peptides . CD10 was shown to be one of the markers for a natural killer cell-restricted progenitor in fetal and adult tissues . Studies also suggest CD10 as a phenotypic marker to distinguish mature neutrophils from immature neutrophils in patients with inflammation . In addition, CD10+GPR77+ carcinoma-associated fibroblasts (CAFs) promote tumor formation and chemoresistance .