CD79a monoclonal antibody

Antigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively . Presence of this receptor complex is essential for B cell development and function . Together these two proteins and the associated B cell receptor (BCR) initiate intracellular signaling following antigen binding . An immunoreceptor tyrosine-based activation motif (ITAM) found in the CD79A intracellular region appears to be important for its function . Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases . Research has shown that CD79A is a marker for B-lineage lymphoblastic leukemia (8). Additionally, investigators have found that mutations in the CD79A (MB1) gene are associated with abnormally low levels of functional B cell receptors in some cases of chronic B cell lymphocytic leukemia .