mTOR (phospho-T2446) polyclonal antibody

mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.

The mTOR Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of mammalian target of rapamycin (mTOR) protein. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

mTOR is a key regulator of cell growth, proliferation, and survival, making it an important target for research in various fields, including cancer, aging, and neurodegenerative diseases. The mTOR Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence.

With its exceptional performance, this antibody enables accurate and reliable detection of mTOR protein expression and activation levels in a wide range of sample types, including cell lysates, tissue homogenates, and cultured cells. Its high affinity and low background ensure precise and reproducible results, allowing researchers to confidently analyze mTOR signaling pathways and investigate its role in disease progression.

The mTOR Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size, allowing for multiple experiments without compromising quality. Each batch is rigorously tested to meet the highest standards of quality control, ensuring consistent performance and reproducibility.

In summary, the mTOR Polyclonal Antibody is a reliable and versatile tool for researchers studying mTOR signaling pathways. Its high specificity, sensitivity, and consistency make it an essential component in the investigation of cellular processes and disease mechanisms.