PKC δ/RKCD (phospho-S664) polyclonal antibody

Protein kinase C (PKC) family members influence a variety of cellular functions, including cell growth, cell differentiation, hormone secretion and membrane function. PKC isoforms are calcium and phospholipid-dependent serine/threonine protein kinases. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKC δ phosphorylation on Thr 507 mediates inhibition of JAK2 and Stat3 function. PKC δ phosphorylates and associates with Stat3 on Ser 727 following induction by IL-6 to negatively regulate the DNA binding and transcriptional activity of Stat3. The Tyr 525, 523 and 565 residues in the catalytic domain are crucial for activation of PKC δ. The Tyr 52, 155 and 187 residues of PKC δ reside within a regulatory domain. The residue Ser 643 appears to be an autophosphorylation site.