B-RAF (phospho-S446) polyclonal antibody

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126).May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179).