AK2 polyclonal antibody

Adenylate kinases 1-5 (designated AK1-5) are a set of enzymes that regulate the phosphorylation state of intracellular adenine nucleotides, which are the principle high-energy phosphoryl-carrying molecules in living cells. AKs influence metabolic signals, which include gene expression, ion channel activity and protein kinase-mediated signaling, by catalyzing phosphoryl transfer between adenine nucleotides (AMP, ADP, ATP). Inherited mutations leading to AK deficiencies in erythrocytes have been implicated in hemolytic anemia. AK2 is found in the mitochondria of liver and heart tissues and is the only AK that localizes to the mitochondrial intermembrane space. In apoptotic cells, AK2 is the only AK that translocates into the cytosol concomitantly with cytochrome c, suggesting that only intermembrane proteins are released from mitochondria during the early stages of apoptosis.