SERPING1 polyclonal antibody

The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of complement activation, blood coagulation, programmed cell death and cell development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The most abundant serpins in human plasma are a-1-antitrypsin (AAT) and a-1-antichymotrypsin (AACT). Other serpin family members include pigment epithelium-derived growth factor (PEDF), human protease nexin 1 (PN-1), protease inhibitor 6 (PI-6), thyroxine-binding globulin precursor (TBG), protease inhibitor 9 (PI-9), serine protease inhibitor 3 (Spi3), plasma protease C1 inhibitor (C1INH), Headpin, SerpinB12, monocyte/neutrophil elastase inhibitor members 1a,1b and 1c (M/NEI) and squamous cell carcinoma antigens 1 and 2 (SCCA1/2). Antithrombin-III (ATIII) is a crucial serine protease inhibitor that regulates the coagulation cascade in blood and inhibits Thrombin.