ADAM22 polyclonal antibody

The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract. ADAM22 and ADAM23 (designated MDC2 and MDC3, respectively) are structurally similar proteins that contain a disrupted zinc-binding motif, and both are highly expressed in brain (4-6). The genes encoding human ADAM22 and ADAM23 map to chromosomes 7q21 and 2q33, respectively.