TCL1B polyclonal antibody

T cell leukemia/lymphoma protein 1B (TCL-1B), also designated TML1, TCL/MTCP1-like 1, syncytiotrophoblast-specific protein and SYN-1, is involved in T cell prolymphocytic leukemia (T-PLL). TCL-1B is located within the region on human chromosome 14q32.1 which, in T cell leukemias and lymphomasis, is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci. TCL-1B is activated by chromosomal rearrangements involving the TCL1 locus. In mouse, TCL-1B is represented by five homologues, TCL-1B1-TCL-1B5. The crystal structure of TCL-1B suggests that it may play a role in the transport of small molecules such as retinoids, nucleotides and fatty acids. TCL-1B is found in both the nucleus and the cytoplasm of normal bone marrow and peripheral lymphocytes.