PIP polyclonal antibody

Gross cystic disease fluid protein 15 (GCDFP-15) is a major protein component of benign breast gross cysts. It is a known marker of breast cancer, as it is found in approximately 50% of all breast cancer specimens. GCDFP-15, also known as PIP, for prolactin inducible protein, is a prolactin and androgen controlled protein. It is detectable in saliva, tears, sweat, seminal plasma, submucosal glands of the lung and amniotic fluid. PIP, the gene encoding GCDFP-15 is expressed in exocrine glands and, in pathologic conditions, in breast cysts and breast cancers exhibiting apocrine features. The PIP gene maps to the long arm of chromosome 7, a region frequently altered in mammary tumors.