YARS polyclonal antibody

Tryptophanyl-tRNA synthetases are essential enzymes that catalyze the aminoacylation of tRNA(Trp) with tryptophan, an essential function of the cell’s protein synthesis machinery. Two forms of tryptophanyl-tRNA synthetase exist; a cytoplasmic form, named TrpRS (also known as WARS), and a mitochondrial form, named WARS2. In normal cells, human TrpRS exists as a full length form and as a truncated form designated mini TrpRS, which is produced by alternative splicing. Expression of mini TrpRS is highly stimulated in human cells by the addition of IFN-g. Although both human full length TrpRS and mini TrpRS are enzymatically active in aminoacylation, they differ in angiostatic activity. The tyrosyl-tRNA synthetase (TyrRS), a protein related to TrpRS, exists as a homodimeric enzyme that catalyzes the aminoacylation of tRNA(Tyr) by L-tyrosine.