NKIRAS1 polyclonal antibody

Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IκBinteracting Ras-like proteins, κB-Ras1 and κB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, κB-Ras1 and κB-Ras2, interact with the PEST domains of IκBa and IκBb and decrease
their rate of degradation. κB-Ras2 shows 71% identity to κB-Ras1. In cells,κB-Ras proteins are associated only with NFκB:IκBb complexes and therefore may provide an explanation for the slower rate of degradation of IκBb compared with IκBa.