ATF4 Polyclonal Antibody

ATF4 Polyclonal Antibody

The ATF4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Activating Transcription Factor 4 (ATF4) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminus of human ATF4 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

The ATF4 protein is a transcription factor that plays a crucial role in regulating gene expression in response to various cellular stresses, including nutrient deprivation, hypoxia, and endoplasmic reticulum (ER) stress. Dysregulation of ATF4 expression has been implicated in the pathogenesis of several diseases, including cancer, diabetes, and neurodegenerative disorders. Therefore, the ATF4 Polyclonal Antibody is an essential tool for researchers studying the molecular mechanisms underlying these diseases.

This antibody has been extensively tested for its specificity and sensitivity in detecting ATF4 protein in various cell lines and tissues. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results. The antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

In summary, the ATF4 Polyclonal Antibody is a high-quality research tool that enables the detection of ATF4 protein in various biological samples. Its specificity, sensitivity, and versatility make it an essential reagent for researchers studying the role of ATF4 in cellular stress responses and disease pathogenesis.