L2HGDH Polyclonal Antibody

L2HGDH Polyclonal Antibody

The L2HGDH polyclonal antibody is a highly specific and sensitive tool designed for the detection and analysis of L2HGDH protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the L2HGDH protein.

L2HGDH, also known as L-2-hydroxyglutarate dehydrogenase, is an enzyme that plays a crucial role in the metabolism of L-2-hydroxyglutarate (L-2HG), a metabolite involved in various physiological processes. Dysregulation of L2HGDH has been implicated in several diseases, including L-2-hydroxyglutaric aciduria, a rare metabolic disorder characterized by the accumulation of L-2HG in the body.

The L2HGDH polyclonal antibody has been rigorously tested for its specificity and sensitivity in various experimental conditions. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. This antibody has been validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

In Western blotting, the L2HGDH polyclonal antibody recognizes a single band of the expected molecular weight, confirming its specificity for L2HGDH protein. In immunohistochemistry, it shows strong staining in tissues known to express L2HGDH, while minimal to no staining is observed in negative control tissues. In immunofluorescence, this antibody exhibits a distinct and specific staining pattern in cells expressing L2HGDH, enabling the visualization and localization of the protein within the cellular context.

The L2HGDH polyclonal antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended to store the antibody at -20°C upon receipt to maintain its stability and activity. With its high specificity, sensitivity, and versatility, the L2HGDH polyclonal antibody is an indispensable tool for researchers studying L2HGDH protein expression and its role in various biological processes and diseases.