KRT14 Polyclonal Antibody

KRT14 Polyclonal Antibody

The KRT14 polyclonal antibody is a highly specific and sensitive tool for the detection and quantification of keratin 14 (KRT14) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human KRT14 protein. The resulting polyclonal antibody is purified using protein A affinity chromatography and validated for its specificity and sensitivity using various techniques, including Western blotting, immunohistochemistry, and ELISA.

KRT14 is a type I intermediate filament protein that is expressed in basal cells of stratified epithelia, including the skin, hair follicles, and oral mucosa. It plays a crucial role in maintaining the structural integrity of these tissues and is involved in various cellular processes, such as cell migration, proliferation, and differentiation. Aberrant expression or mutations in KRT14 have been associated with several human diseases, including epidermolysis bullosa simplex, a genetic skin disorder characterized by blistering and erosions of the skin and mucous membranes.

The KRT14 polyclonal antibody is a valuable tool for researchers studying the role of KRT14 in normal and pathological conditions. It can be used to detect and quantify KRT14 protein levels in various biological samples, including tissue lysates, cell lysates, and serum. It can also be used for immunohistochemical staining of tissue sections to visualize the distribution and localization of KRT14 protein in different tissues. The high specificity and sensitivity of this antibody make it an ideal choice for both basic research and clinical applications.