SMAD7 Polyclonal Antibody

SMAD7 Polyclonal Antibody

The SMAD7 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of SMAD7 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human SMAD7 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The SMAD7 protein is a member of the SMAD family of proteins, which play a critical role in the TGF-β signaling pathway. SMAD7 acts as a negative regulator of TGF-β signaling by inhibiting the phosphorylation of SMAD2 and SMAD3, which are downstream effectors of the pathway. Dysregulation of SMAD7 expression has been implicated in various diseases, including cancer, fibrosis, and inflammation.

The SMAD7 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting SMAD7 protein in various cell lines and tissues. It has been shown to detect endogenous SMAD7 protein in Western blotting and immunohistochemistry assays with high specificity and sensitivity. Additionally, this antibody has been shown to be compatible with various sample types, including human, mouse, and rat tissues.

In summary, the SMAD7 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of SMAD7 protein in various biological samples. Its high specificity and sensitivity make it an excellent tool for studying the role of SMAD7 in various diseases and for developing new therapeutic strategies targeting the TGF-β signaling pathway.