KCNK18 Polyclonal Antibody

KCNK18 Polyclonal Antibody

The KCNK18 polyclonal antibody is a highly specific and sensitive tool for the detection and analysis of KCNK18 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human KCNK18 protein. The resulting polyclonal antibody is purified using a combination of protein A and protein G affinity chromatography to ensure high purity and specificity.

The KCNK18 protein, also known as TWIK-related acid-sensitive K+ channel 2 (TASK-2), is a member of the two-pore domain potassium channel family. It plays a critical role in regulating the resting membrane potential and excitability of various cell types, including neurons, smooth muscle cells, and epithelial cells. Dysregulation of KCNK18 expression or function has been implicated in various pathological conditions, such as hypertension, epilepsy, and cancer.

The KCNK18 polyclonal antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 50 kDa in Western blot analysis of human, mouse, and rat tissue lysates. In addition, it shows strong staining of KCNK18 protein in various human and mouse tissues, including brain, kidney, lung, and heart.

Overall, the KCNK18 polyclonal antibody is a reliable and versatile tool for the detection and analysis of KCNK18 protein expression in various biological samples. Its high specificity and sensitivity make it an ideal choice for basic research, drug discovery, and diagnostic applications.