Neurofibromin Polyclonal Antibody

Ab type

Primary antibody

Background

NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

319372

synonyms

NF1; Neurofibromin; Neurofibromatosis-related protein NF-1