NDEL1 Antibody

Size

100ul

Clone Number

Aliases

A. nidulans antibody; DKFZp451M0318 antibody; ENDOOLIGOPEPTIDASE A antibody; EOPA antibody; MITAP 1 antibody; MITAP1 antibody; Mitosin associated protein 1 antibody; Mitosin associated protein MITAP1 antibody; Mitosin-associated protein 1 antibody; Ndel 1 antibody; NDEL1 antibody; NDEL1_HUMAN antibody; Nuclear distribution gene E like homolog 1 antibody; Nuclear distribution protein nudE like 1 antibody; Nuclear distribution protein nudE-like 1 antibody; NUDE like protein antibody; NudE nuclear distribution gene E homolog like 1 A. nidulans antibody; NudE nuclear distribution gene E homolog like 1 antibody; NUDEL antibody; Protein Nudel antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9GZM8

Immunogen

Recombinant Human Nuclear distribution protein nudE-like 1 protein (1-345AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NDEL1

Research Areas

Neuroscience; Cell biology; Signal transduction