NDC80 Antibody

Size

100ug

Clone Number

Aliases

from Entrez Gene , antibody; HEC antibody; Highly expressed in cancer antibody; Highly expressed in cancer protein antibody; Highly expressed in cancer rich in leucine heptad repeats antibody; HsHec1 antibody; hsNDC80 antibody; Kinetochore associated 2 antibody; Kinetochore associated protein 2 antibody; Kinetochore protein Hec1 antibody; Kinetochore protein NDC80 homolog antibody; Kinetochore-associated protein 2 antibody; KNTC2 antibody; ndc80 antibody; NDC80 homolog kinetochore complex component antibody; NDC80 kinetochore complex component homolog antibody; NDC80, S. cerevisiae, homolog of antibody; NDC80_HUMAN antibody; Retinoblastoma associated protein HEC antibody; Retinoblastoma-associated protein HEC antibody; TID3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O14777

Immunogen

Recombinant Human Kinetochore protein NDC80 homolog protein (1-249AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NDC80

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cell biology