NCOA1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

bHLHe74 antibody; Class E basic helix-loop-helix protein 74 antibody; F SRC 1 antibody; Hin 2 protein antibody; Hin2 protein antibody; MGC129719 antibody; MGC129720 antibody; mNRC 1 antibody; NCoA 1 antibody; NCoA-1 antibody; Ncoa1 antibody; NCOA1_HUMAN antibody; Nuclear receptor coactivator 1 antibody; Nuclear receptor coactivator protein 1 antibody; NY REN 52 antigen antibody; Protein Hin 2 antibody; Protein Hin-2 antibody; Protein Hin2 antibody; Renal carcinoma antigen NY REN 52 antibody; Renal carcinoma antigen NY-REN-52 antibody; RIP 160 antibody; RIP160 antibody; SRC 1 antibody; SRC-1 antibody; Steroid receptor coactivator 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15788

Immunogen

Recombinant Human Nuclear receptor coactivator 1 protein (284-393AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NCOA1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction