Nampt Antibody

Size

100ul

Clone Number

Aliases

Nampt antibody; Pbef1 antibody; Nicotinamide phosphoribosyltransferase antibody; NAmPRTase antibody; Nampt antibody; EC 2.4.2.12 antibody; Pre-B-cell colony-enhancing factor 1 homolog antibody; PBEF antibody; Visfatin antibody

Immunogen Species

Rattus norvegicus (Rat)

UniProt ID

Q80Z29

Immunogen

Recombinant Rat Nampt protein (231-491AA)

Raised in

Rabbit

Species Reactivity

Rat, Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Background

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

Nampt

Research Areas

Epigenetics and Nuclear Signaling